Learn more about the science involved

ReCverin LLC is founded in the science of Vitamin C, with particular focus on the oxidized form called DHAA. We believe that the more you know about this science, the more you will appreciate the value of our products.


We believe the most reliable information can be found in scientific literature. Therefore we dedicate this page of our website to a bibliography of titles, with links to the articles, which are pertinent to a general understanding of Vitamin C, with specific emphasis on DHAA. These titles are selected because the research contains experimental data that illustrates the chemical nature or biological behavior of Vitamin C.


ReCverin LLC does not necessarily agree with the interpretations or conclusions drawn from that data by the authors. In particular, any statements about disease found in any of these articles are strictly the opinions of their respective authors. Our products are not intended to diagnose, treat, cure, or prevent any disease.

(2019)  Metabolic control by dehydroascorbic acid: Questions and controversies in cancer cells


(2019) Vitamin C as a Modulator of the Response to Cancer Therapy  


(2018) Pharmacological Ascorbate Suppresses Growth of Gastric Cancer Cells with GLUT1 Overexpression and Enhances the Efficacy of Oxaliplatin Through Redox Modulation


(2017) The SLC2A14 gene, encoding the novel glucose/dehydroascorbate

transporter GLUT14, is associated with inflammatory bowel disease 


(2016) Arterial Tortuosity Syndrome reveals function of dehydroascorbic acid in collagen and elastin synthesis: Implications for skin care


(2016) L-dehydroascorbic acid can substitute L-ascorbic acid as dietary vitamin C source in guinea pigs


(2016) Genetic Variation in Human Vitamin C Transporter Genes in Common Complex Diseases


(2015) Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH


(2015) Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid


(2015) Dehydroascorbic Acid Attenuates Ischemic Brain Edema and Neurotoxicity in Cerebral Ischemia: An in vivo Study


(2015) GLUT10 deficiency leads to oxidative stress and non-canonical alpha-v beta-3 integrin-mediated TGF-beta signaling associated with extracellular matrix disarray in arterial tortuosity syndrome skin fibroblasts


 (2015) Comparative study on postharvest performance of nectarines grown under regulated deficit irrigation


 (2015) Effect of Glucose on GLUT1-Dependent Intracellular Ascorbate Accumulation and Viability of Thyroid Cancer Cells 

(2014) Vitamin C Deficiency – Part 3


(2014) Vitamin C Transporters, Recycling and the Bystander Effect in the Nervous System: SVCT2 versus Gluts


(2014) The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism


(2014) Orally Administrated Ascorbic Acid Suppresses Neuronal Damage and Modifies Expression of SVCT2 and GLUT1 in the Brain of Diabetic Rats with Cerebral Ischemia-Reperfusion


(2014) Human erythrocytes transport dehydroascorbic acid and sugars using the same transporter complex


(2014) Subcellular compartmentation of ascorbate and its variation in disease states


 (2014) Role of GLUT1 in regulation of reactive oxygen species 

 

(2013) Regulation of Vitamin C Homeostasis during Deficiency


(2013) Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive cancers, suggesting potential utility for sodium bicarbonate and dehydroascorbic acid in cancer therapy


(2013) Intestinal Dehydroascorbic Acid (DHA) Transport Mediated by the Facilitative Sugar Transporters, GLUT2 and GLUT8


(2012) Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells


(2012) Studies with low micromolar levels of ascorbic and dehydroascorbic acid fail to unravel a preferential route for vitamin C uptake and accumulation in U937 cells


(2011) High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigs


(2011) Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury


(2011) Hyperpolarized [1-13C]-Ascorbic and Dehydroascorbic Acid: Vitamin C as a Probe for Imaging Redox Status in Vivo

 

(2010) Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome 


(2010) Glucose transporter 10 and arterial tortuosity syndrome: The vitamin C connection 


(2009) Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2 


(2008) Antiviral effects of ascorbic and dehydroascorbic acids in vitro 


(2008) Vitamin C transporters 


(2007) Vitamin C Is an Essential Antioxidant That Enhances Survival of Oxidatively Stressed Human Vascular Endothelial Cells in the Presence of a Vast Molar Excess of Glutathione 


(2007) Vitamin C: Biosynthesis, recycling and degradation in mammals 


(2006) Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium 


(2005) Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint 


(2004) Vitamin C inhibits hypoxia-induced damage and apoptotic signaling pathways in cardiomyocytes and ischemic hearts 


(2004) Vitamin C Is a Kinase Inhibitor: Dehydroascorbic Acid Inhibits IκBα Kinase β

 (2004) Human Erythrocyte Recycling of Ascorbic Acid: Relative Contributions from the Ascorbate Free Radical and Dehydroascorbic Acid 


 (2003) Recycling of Vitamin C by a Bystander Effect 


 (2002) Vitamin C Prevents DNA Mutation Induced by Oxidative Stress 


 (2001) US Patent 6,221,904: Method for increasing the concentration of ascorbic acid in brain tissues of a subject 


 (2000) Ascorbate oxidation is a prerequisite for its transport into rat liver microsomal vesicles 


 (2000) Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C 


 (2000) Glucose Modulates Vitamin C Transport in Adult Human Small Intestinal Brush Border Membrane Vesicles 


 (1998) Absorption, transport, and disposition of ascorbic acid in humans 


 (1998) Characterization of skin permeation of vitamin C: theoretical analysis of penetration profiles and differential scanning calorimetry study 


 (1997) Glucose Transporter Isoforms GLUT1 and GLUT3 Transport Dehydroascorbic Acid 


 (1996) Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients 


 (1996) Purification, cloning and expression of dehydroascorbic acid-reducing activity from human neutrophils: identification as glutaredoxin 


 (1996) Gluconeogenesis from ascorbic acid: ascorbate recycling in isolated murine hepatocytes 


 (1995) Accumulation of Vitamin C (Ascorbate) and Its Oxidized Metabolite Dehydroascorbic Acid Occurs by Separate Mechanisms 


 (1994) Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin 


 (1994) Dose-Response Effects of Acute Ultraviolet Irradiation on Antioxidants and Molecular Markers of Oxidation in Murine Epidermis and Dermis 


 (1993) Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions 


 (1993) Ascorbic acid recycling in human neutrophils 


 (1991) Ascorbate- and dehydroascorbic acid-mediated reduction of free radicals in the human erythrocyte 


(1983) Enhancement of Antitumor Activity of Ascorbate against Ehrlich Ascites Tumor Cells by the Copper:Glycylglycylhistidine Complex--Linus Pauling


 (1982) The Reversibility of the Vitamin C Redox System: Electrochemical Reasons and Biological Aspects 


 (1966) Autoradiographic Studies on the Distribution of C14-labelled Ascorbic Acid and Dehydroascorbic Acid 


 (1956) Aging: A Theory Based on Free Radical and Radiation Chemistry--by Denham Harman 


 (1944) Water Soluble Vitamins in Sweat 


 (1937) The Oxidation of Ascorbic Acid and its Reduction In Vitro and In Vivo 


 (1936) Vitamin C in Vegetables: Ascorbic Acid Oxidase 


 (1934) The urinary excretion of ascorbic and dehydroascorbic acids in man 


 (1931) On the Function of Hexuronic Acid in the Respiration of the Cabbage Leaf-- by Albert Szent-Györgyi